Table 2.
Association between the miR-34a polymorphisms and risk of IS.
| SNPs | Controls (n = 560) | IS patients (n = 548) | OR (95% CI)† | P†, PBH |
|---|---|---|---|---|
| rs12128240 | ||||
| CC | 334 (59.6) | 329 (60.0) | 1.00(ref) | |
| CT | 187(33.4) | 182(33.2) | 0.94(0.57–1.66) | 0.874, 0.874 |
| TT | 39(7.0) | 37(6.8) | 0.96(0.56–1.79) | 0.826, 0.826 |
| TT+CT vs. CC | 0.97(0.74–1.50) | 0.832, 0.866 | ||
| TT vs. CC+CT | 1.17(0.66–1.82) | 0.854, 0.854 | ||
| C | 855(76.3) | 840(76.6) | 1.00(ref) | |
| T | 265(23.7) | 256(23.4) | 0.98(0.78–1.44) | 0.808,0.808 |
| rs2666433 | ||||
| GG | 286(51.1) | 265(48.4) | 1.00(ref) | |
| GA | 228(40.7) | 216(39.4) | 1.05(0.77–1.39) | 0.868, 0.874 |
| AA | 46(8.2) | 67(12.2) | 1.61(1.05–2.52) | 0.031, 0.093 |
| AA+GA vs. GG | 1.18(0.86–1.51) | 0.368, 0.866 | ||
| AA vs. GG+GA | 1.58(1.05–2.45) | 0.026, 0.078 | ||
| G | 800(71.4) | 746(68.1) | 1.00(ref) | |
| A | 320(28.6) | 350(31.9) | 1.23(0.94–1.52) | 0.086, 0.258 |
| rs6577555 | ||||
| CC | 353(63.0) | 344(62.8) | 1.00(ref) | |
| CA | 188(33.6) | 179(32.7) | 0.95(0.71–1.51) | 0.803, 0.874 |
| AA | 19(3.4) | 25(4.5) | 1.30(0.65-2.92) | 0.301, 0.451 |
| AA+CA vs. CC | 1.08(0.74–1.61) | 0.866, 0.866 | ||
| AA vs. CC+CA | 0.86(0.53–1.78) | 0.347, 0.520 | ||
| C | 894(79.8) | 867(79.1) | 1.00(ref) | |
| A | 226(20.2) | 229(20.9) | 1.10(0.83–1.36) | 0.629, 0.808 |
Ref: reference; OR: odds ratio; CI: confidence interval. †Adjusted by gender, age, smoker, diabetes and hypertension. BHCorrected by B-H method. P < 0.05 were indicated in bold font.