Figure 1.

Change in neurovascular interface is involved in inflammatory, immune and neurodegenerative responses in multiple sclerosis. Disruption or increased permeability of blood-brain barrier cause the leakage of hemostasis components into the brain parenchyma, which triggers the coagulation cascade. In turn, hemostasis components foster the inflammatory response and the immune activation, sustaining neurodegenerative events in MS. NAWM, normal-appearing white matter; ROS, reactive oxygen species.