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. 2019 Apr 30;9:6673. doi: 10.1038/s41598-019-43217-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Evaluation of the clinical score over time of C57BL/6 female mice immunized with MOG_35-55 emulsified with CFA, treated with Dexamethasone (DEX, 50 mg/kg) or Fingolimod (FTY-720, 10 mg/kg) at the day of immunization. (A) The schematic timeline for the experimental design. (B) Treatment with DEX on the day of immunization protected against EAE clinical score evolution; dotted arrows indicate the day of the euthanasia. (C) The sum of the total score from each animal at the 26 dpi was used to determine disease severity. (D) Hematoxylin-Eosin staining of mice spinal cord, arrows showed infiltrating clusters of peripheral cells in EAE and EAE + DEX. (E) Density of infiltrating cells in the white matter of EAE and EAE + DEX spinal cords/100 μm². The results are showed as mean ± SEM of the experimental groups (N = 18). *p < 0.05 vs EAE [Two-way ANOVA followed by Bonferroni post-test (B), bi-caudal T-test (C) and Mann-Whitney non-parametric test (E)].