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. 2019 Apr 30;9:6673. doi: 10.1038/s41598-019-43217-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DnGR hippocampal CA1 administration reversed memory impairment in EAE + DEX animals at the 8 d.p.i. (A) GFP positive neurons in CA1 infected with DnGR. (B) Both p1005 and DnGR mice did not show differences in the discrimination ratio in the training day, at the 7 d.p.i. (C) Hippocampal DnGR overexpression protected against the EAE- induced decrease in memory consolidation 2 and (D) 24 hour after training in NOR test. EGR1 expression in dorsal hippocampus of EAE + DEX transfected with DnGR. Full arrows represent HSV-GFP transfection in fibers of hippocampus. Dashed arrows represent EGR-1 positive cell in CA1 of hippocampus. Representative photomicrographs (4x and 20x) of the immunofluorescence assay. Results are shown as mean + SEM. *p < 0.05 vs EAE + DEX/p1005 group. Mann-Whitney non-parametric test, n = 6 for each group.