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. 2019 Apr 24;10:270. doi: 10.3389/fphys.2019.00270

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Copyright © 2019 Smith, Martínez, Martínez and McCulloch.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In this model, collagen-coated nylon grids of varying widths are created to assess the impact of lateral boundary sensing by periodontal fibroblasts. A collagen gel is prepared using the nylon grids. Image shows nylon grids (200 × 200 μm) treated with collagen. Cells were stained with DAPI to reveal the cell nuclei (A). Cells cultured within the grid can be studied using immunofluorescence to identify cellular extensions (B) or to reveal collagen fiber organization and remodeling using the reflectance mode of the confocal microscope (C). Images in this figure represent reanalysis of previously published data in Mohammadi et al., 2014.