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. 2019 Mar 30;46(2):193–210. doi: 10.1007/s10928-019-09629-4

Table 1.

Parameter list with nominal values for the cortisol model in [15] together with initial values and property

Parameter Nominal value Property Initial value
Input rate constant, k1 (1/min) 0.0666 Linear 1
Output rate constant, k2 (1/min) 0.0333 Linear 0.01
Constant, α (μg/100 ml) 0.7 Nonlinear 0.01
Constant, β (μg/100 ml) 1 Nonlinear 0.1
Phase, tf (min) 250 Nonlinear 0.1
Delay, d (min) 70 Nonlinear 50
Fixed switch exponent, n 10 Nonlinear Fixed

Parameters that enter in a linear fashion were estimated using adaptive chaos synchronization while the parameters that enter in a nonlinear fashion were estimated by combining grid search with adaptive chaos synchronization