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. 2019 Apr 24;10:768. doi: 10.3389/fimmu.2019.00768

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Copyright © 2019 van Zelm, Bosco, Aui, De Jong, Hore-Lacy, O'Hehir, Stirling and Cameron.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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B-cell defects in STAT1 GOF. (A) Somatic hypermutation levels in IgG subclass transcripts of the patient and controls. (B) Relative distributions of IgG subclasses of unique transcripts. (C) STAT3 phosphorylation in EBV-LCL upon stimulation with IL-21. (D) Nuclear localization of pSTAT3 in EBV-LCL following stimulation with IL-21 as determined with the AMNIS ImageStream. Example images are shown on the left, and the collated events as overlays for nuclear localization scores on the right. (E) CD25 (IL2Rα) expression on EBV-LCL following stimulation with IL-21. Overlays are shown for one experiment to illustrate on the left and the combined data from 4 independent experiments on the right. Statistics: Paired t-test.