Table 1.
Fold changes in MNC gene expression in lean and obese subjects 2 and 6 h after consuming 3 isocaloric liquid mixed meals.
HC meal | HF meal | HP meal | Main effects | Interaction effects | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Δ 2 h | Δ 6 h | Δ 2 h | Δ 6 h | Δ 2 h | Δ 6 h | Group | Time | Meal | Group × Meal | Group × Time | Meal × Time | ||
CYBB | LIS | 1.10 ± 0.18 | 0.89 ± 0.25 | 1.23 ± 0.19 | 1.13 ± 0.17 | 1.18 ± 0.13 | 0.97 ± 0.12 | 0.132 | 0.005 | 0.309 | 0.202 | 0.007 | 0.839 |
OIR | 1.15 ± 0.12 | 1.35 ± 0.11 | 1.10 ± 0.08 | 1.28 ± 0.16 | 1.35 ± 0.13 | 1.50 ± 0.24 | |||||||
CYBA | LIS | 1.07 ± 0.08 | 0.94 ± 0.23 | 1.13 ± 0.14 | 1.05 ± 0.08 | 1.11 ± 0.08 | 1.00 ± 0.04 | 0.758 | 0.167 | 0.870 | 0.446 | 0.006 | 0.845 |
OIR | 0.94 ± 0.04 | 1.24 ± 0.15 | 0.92 ± 0.05 | 1.12 ± 0.10 | 1.07 ± 0.09 | 1.16 ± 0.11 | |||||||
NCF1 | LIS | 1.12 ± 0.12 | 1.10 ± 0.16 | 1.14 ± 0.12 | 1.41 ± 0.27 | 1.01 ± 0.06 | 1.15 ± 0.10 | 0.350 | 0.002 | 0.416 | 0.182 | 0.730 | 0.811 |
OIR | 0.88 ± 0.07 | 1.09 ± 0.14 | 0.97 ± 0.06 | 1.15 ± 0.15 | 1.11 ± 0.12 | 1.26 ± 0.13 | |||||||
NCF2 | LIS | 1.09 ± 0.10 | 1.18 ± 0.18 | 1.15 ± 0.13 | 1.33 ± 0.18 | 1.06 ± 0.06 | 1.03 ± 0.09 | 0.099 | 0.017 | 0.495 | 0.088 | 0.348 | 0.761 |
OIR | 0.92 ± 0.07 | 1.01 ± 0.11 | 0.95 ± 0.05 | 1.08 ± 0.12 | 1.06 ± 0.08 | 1.14 ± 0.07 | |||||||
NCF4 | LIS | 1.49 ± 0.32 | 1.64 ± 0.45 | 1.19 ± 0.17 | 1.40 ± 0.24 | 0.98 ± 0.05 | 1.08 ± 0.13 | 0.229 | 0.007 | 0.920 | 0.008 | 0.573 | 0.804 |
OIR | 0.82 ± 0.06 | 1.03 ± 0.15 | 0.94 ± 0.04 | 1.28 ± 0.27 | 1.31 ± 0.30 | 1.28 ± 0.17 | |||||||
SOD1 | LIS | 1.20 ± 0.93 | 2.20 ± 0.97 | 1.70 ± 0.43 | 1.89 ± 0.55 | 1.05 ± 0.08 | 1.29 ± 0.31 | 0.288 | 0.001 | 0.751 | 0.023 | 0.503 | 0.992 |
OIR | 1.02 ± 0.14 | 1.18 ± 0.20 | 1.27 ± 0.19 | 1.33 ± 0.18 | 1.58 ± 0.41 | 1.62 ± 0.32 | |||||||
SOD2 | LIS | 1,20 ± 0.22 | 1.22 ± 0.33 | 1.14 ± 0.15 | 1.37 ± 0.21 | 1.02 ± 0.05 | 1.09 ± 0.08 | 0.932 | 0.005 | 0.350 | 0.252 | 0.822 | 0.388 |
OIR | 0.99 ± 0.12 | 1.00 ± 0.22 | 1.04 ± 0.06 | 1.45 ± 0.24 | 1.15 ± 0.15 | 1.33 ± 0.15 | |||||||
GPx3 | LIS | 1.25 ± 0.12 | 1.29 ± 0.30 | 1.22 ± 0.12 | 1.31 ± 0.11 | 1.17 ± 0.06 | 1.28 ± 0.25 | 0.560 | 0.001 | 0.670 | 0.859 | 0.534 | 0.607 |
OIR | 1.13 ± 0.07 | 1.70 ± 0.41 | 1.18 ± 0.13 | 1.43 ± 0.13 | 1.24 ± 0.16 | 1.23 ± 0.15 | |||||||
TXN | LIS | 1.23 ± 0.23 | 0.94 ± 0.26 | 1.07 ± 0.10 | 1.10 ± 0.08 | 1.29 ± 0.11 | 1.13 ± 0.13 | 0.161 | 0.001 | 0.059 | 0.859 | 0.057 | 0.435 |
OIR | 1.07 ± 0.05 | 1.27 ± 0.10 | 1.16 ± 0.11 | 1.27 ± 0.11 | 1.38 ± 0.18 | 1.42 ± 0.17 | |||||||
TXNRD1 | LIS | 1.22 ± 0.26 | 1.09 ± 0.34 | 1.16 ± 0.21 | 1.18 ± 0.15 | 1.26 ± 0.11 | 1.04 ± 0.10 | 0.096 | 0.001 | 0.218 | 0.446 | 0.046 | 0.588 |
OIR | 1.14 ± 0.09 | 1.29 ± 0.09 | 1.31 ± 0.16 | 1.51 ± 0.17 | 1.49 ± 0.21 | 1.53 ± 0.19 | |||||||
Nrf2 | LIS | 1.32 ± 0.29 | 1.42 ± 0.35 | 1.16 ± 0.14 | 1.40 ± 0.18 | 1.06 ± 0.06 | 1.12 ± 0.09 | 0.874 | 0.001 | 0.619 | 0.137 | 0.975 | 0.834 |
OIR | 1.17 ± 0.10 | 1.32 ± 0.11 | 1.12 ± 0.09 | 1.28 ± 0.10 | 1.29 ± 0.16 | 1.34 ± 0.13 |
Significant values (P < 0.05) are indicated in bold.