Table 2.
Pharmacokinetics parameters.
| No AR (120) | TCMAR (n = 17) | SCR (n = 8) | No AR vs. TCMAR | No AR vs. SCR | TCMAR vs. SCR | |
|---|---|---|---|---|---|---|
| 1st Week | 1st Week | 1st Week | P value | P value | P value | |
| TAC dose (mg/day) | 4.0 ± 2.3 | 4.5 ± 2.1 | 5.0 ± 2.0 | 0.739 | 0.793 | 0.889 |
| Cmin TAC (ng/mL) | 5.5 ± 3.5 | 5.0 ± 3.4 | 6.0 ± 2.4 | 0.779 | 0.894 | 0.961 |
| CsA dose (mg/day) | 300.0 ± 142.1 | 650.0 ± 212.1 | 500.0 ± 125.3 | 0.059 | 0.333 | 0.667 |
| Cmin CsA (ng/mL) | 177.0 ± 83.9 | 105.6 ± 67.1 | 125.3 ± 56.4 | 0.134 | 0.083 | 0.500 |
| Prednisone (mg/day) | 20 ± 4.1 | 20 ± 4.3 | 20 ± 6.5 | 0.753 | 0.398 | 0.448 |
| MPA dose (mg/day) | 2000 ± 468.1 | 2000 ± 333.3 | 2000 ± 250.5 | 0.424 | 0.616 | 0.909 |
| No AR (123) | TCMAR (n = 14) | SCR (n = 8) | No AR vs. TCMAR | No AR vs. SCR | TCMAR vs. SCR | |
| Day 15th | Day 15th | Day 15th | P-value | P-value | P-value | |
| TAC dose (mg/day) | 6.0 ± 2.9 | 7.0 ± 1.9 | 5.5 ± 1.8 | 0.661 | 0.703 | 0.571 |
| Cmin TAC (ng/mL) | 5.8 ± 2.3 | 4.9 ± 1.5 | 5.2 ± 1.9 | 0.339 | 0.811 | 0.827 |
| CsA dose (mg/day) | 400.0 ± 110.7 | 500.0 ± 141.4 | 395.0 ± 105.2 | 0.333 | 0.500 | 0.667 |
| Cmin CsA (ng/mL) | 144.0 ± 91.2 | 186.3 ± 10.9 | 150.2 ± 11.5 | 0.436 | 0.200 | 0.667 |
| Prednisone (mg/day) | 20 ± 1.1 | 20 ± 1.0 | 20 ± 0.5 | 0.843 | 0.919 | 1.000 |
| MPA dose (mg/day) | 2000 ± 522.4 | 2000 ± 408.2 | 2000 ± 350.5 | 0.733 | 0.589 | 0.857 |
| No AR (129) | TCMAR (n = 8) | SCR (n = 8) | No AR vs. TCMAR | No AR vs. SCR | TCMAR vs. SCR | |
| 1st Month | 1st Month | 1st Month | P-value | P-value | P-value | |
| TAC dose (mg/day) | 8.0 ± 2.8 | 4.0 ± 2.9 | 4.5 ± 0.7 | 0.030 | 0.045 | 0.800 |
| Cmin TAC (ng/mL) | 7.1 ± 2.4 | 5.5 ± 2.3 | 6.6 ± 1.9 | 0.608 | 0.833 | 0.573 |
| CsA dose (mg/day) | 300.0 ± 122.4 | 400.0 ± 120.2 | 300. ± 1.77.2 | 0.600 | 0.400 | 0.317 |
| Cmin CsA (ng/mL) | 194.2 ± 109.2 | 238.6 ± 65.5 | 225.5 ± 56.3 | 0.870 | 0.273 | 0.667 |
| Prednisone (mg/day) | 20 ± 2.3 | 20 ± 2.2 | 20 ± 2.5 | 0.957 | 0.913 | 0.905 |
| MPA dose (mg/day) | 2000 ± 543.3 | 2000 ± 520.3 | 2000 ± 495.6 | 0.246 | 0.246 | 0.958 |
| No AR (133) | TCMAR (n = 4) | SCR (n = 8) | No AR vs. TCMAR | No AR vs. SCR | TCMAR vs. SCR | |
| 2nd Month | 2nd Month | 2nd Month | P-value | P-value | P-value | |
| TAC dose (mg/day) | 6.0 ± 2.9 | 4.0 ± 1.9 | 4.5 ± 2.1 | 0.130 | 0.104 | 0.48 |
| Cmin TAC (ng/mL) | 7.3 ± 2.8 | 5.2 ± 2.0 | 6.6 ± 2.5 | 0.133 | 0.213 | 0.221 |
| CsA dose (mg/day) | 200.0 ± 98.5 | 400 ± 135.2 | 150.0 ± 95.6 | 0.308 | 0.462 | 0.317 |
| Cmin CsA (ng/mL) | 184.0 ± 53.3 | 310.9 ± 98.5 | 165.2 ± 44.6 | 0.143 | 0.714 | 0.321 |
| Prednisone (mg/day) | 15 ± 4.4 | 12.5 ± 3.5 | 15 ± 4.1 | 0.459 | 0.946 | 0.533 |
| MPA dose (mg/day) | 1500 ± 535.9 | 2000 ± 126.3 | 2000 ± 545.6 | 0.216 | 0.216 | 0.901 |
| No AR (133) | TCMAR (n = 4) | SCR (n = 8) | No AR vs. TCMAR | No AR vs. SCR | TCMAR vs. SCR | |
| 3rd Month | 3rd Month | 3rd Month | P-value | P-value | P-value | |
| TAC dose (mg/day) | 7.0 ± 3.1 | 5.9 ± 2.3 | 5.0 ± 2.2 | 0.157 | 0.549 | 0.317 |
| Cmin TAC (ng/mL) | 7.6 ± 2.9 | 7.5 ± 3.9 | 5.8 ± 1.5 | 0.978 | 0.046 | 0.329 |
| CsA dose (mg/day) | 247.0 ± 98.5 | 250 ± 78.5 | 150.0 ± 89.5 | 0.364 | 0.364 | 0.966 |
| Cmin CsA (ng/mL) | 184.5 ± 56.6 | 239.1 ± 113.8 | 177.5 ± 54.2 | 0.032 | 0.909 | 0.667 |
| Prednisone (mg/day) | 10 ± 4.5 | 7.5 ± 3.5 | 10 ± 5.0 | 0.288 | 0.191 | 0.200 |
| MPA dose (mg/day) | 1000 ± 494.5 | 2000 ± 175.5 | 2000 ± 495.5 | 0.062 | 0.055 | 0.933 |
| No AR (134) | TCMAR (n = 3) | SCR (n = 8) | No AR vs. TCMAR | No AR vs. SCR | TCMAR vs. SCR | |
| 6th Month | 6th Month | 6th Month | P-value | P-value | P-value | |
| TAC dose (mg/day) | 5.0 ± 2.7 | 4.5 ± 2.3 | 5.0 ± 2.1 | 0.444 | 0.810 | 0.756 |
| Cmin TAC (ng/mL) | 7.5 ± 2.2 | 8.5 ± 5.7 | 6.5 ± 2.0 | 0.752 | 0.326 | 0.982 |
| CsA dose (mg/day) | 250.0 ± 58.5 | 300 ± 0 | 150.0 ± 75.9 | 0.126 | 0.200 | 0.317 |
| Cmin CsA (ng/mL) | 149.0 ± 53.1 | 185.5 ± 0 | 173.4 ± 61.5 | 0.800 | 0.827 | 0.735 |
| Prednisone (mg/day) | 5 ± 3.8 | 3.5 ± 1.5 | 5 ± 4.5 | 0.165 | 0.209 | 0.500 |
| MPA dose (mg/day) | 1000 ± 378.2 | Ø | 1500 ± 288.6 | Ø | 0.125 | Ø |
| No AR (134) | TCMAR (n = 3) | SCR (n = 8) | No AR vs. TCMAR | No AR vs. SCR | TCMAR vs. SCR | |
| 9th Month | 9th Month | 9th Month | P-value | P-value | P-value | |
| TAC dose (mg/day) | 5.0 ± 2.1 | 3.0 ± 0 | 4.0 ± 2.6 | 0.069 | 0.089 | 0.835 |
| Cmin TAC (ng/mL) | 7.5 ± 1.9 | 7.7 ± 0 | 8.3 ± 0.9 | 0.966 | 0.422 | 0.655 |
| CsA dose (mg/day) | 200 ± 46.9 | 200 ± 0 | 155.0 ± 65.5 | 0.985 | 0.250 | 0.715 |
| Cmin CsA (ng/mL) | 137.0 ± 40.63 | 170.2 ± 0 | 163.4 ± 69.6 | 0.525 | 0.126 | 0.791 |
| Prednisone (mg/day) | 5 ± 4.3 | 5 ± 2.5 | 5 ± 2.5 | 0.647 | 0.724 | 0.800 |
| MPA dose (mg/day) | 720 ± 422.9 | Ø | 1000 ± 288.7 | Ø | 0.178 | Ø |
| No AR (135) | TCMAR (n = 2) | SCR (n = 8) | No AR vs. TCMAR | No AR vs. SCR | TCMAR vs. SCR | |
| 12th Month | 12th Month | 12th Month | P-value | P-value | P-value | |
| TAC dose (mg/day) | 5.0 ± 2.1 | 3.0 ± 0 | 3.8 ± 0.4 | 0.375 | 0.273 | 0.667 |
| Cmin TAC (ng/mL) | 6.7 ± 2.4 | 12.3 ± 0 | 6.0 ± 2.2 | 0.125 | 0.742 | 0.221 |
| CsA dose (mg/day) | 200.0 ± 77.3 | 200 ± 0 | 150.0 ± 48.6 | 0.958 | 0.526 | 0.712 |
| Cmin CsA (ng/mL) | 144 ± 30.3 | 104.2 ± 0 | 179.5 ± 32.5 | 0.750 | 0.325 | 0.625 |
| Prednisone (mg/day) | 0 | 0 | 0 | 0.667 | 0.886 | 0.500 |
| MPA dose (mg/day) | 860 ± 190.4 | Ø | 1000 ± 250.3 | Ø | 0.727 | Ø |
Bold value of P ≤ 0.05 was considered significant.