Table 1.
Top five transcription factor enriched in gene set corresponding to identified 638 CpGs and its regulated genes.
| Transcription factor | Genes (N) | FDR | Regulated genes |
|---|---|---|---|
| NFATC1 | 47 | 1.48 × 10−8 | SLIT3, RORA, SYT10, CNTNAP2, SCN3A, MRPL28, ADAMTSL1, CTNND2, ESR1, PPM1B, PDE4D, RARB, OPCML, SNX15, PRKD2, ID3, PTPRO, ADCY2, CUL3, DMD, ITM2C, KLF12, BCOR, CTNND1, SGCD, ACACA, HDAC6, POGK, AUTS2, PAX3, DLG2, SLC6A5, SOX5, DLC1, ANTXR1, NGFRAP1, LSAMP, GRM8, CACNA2D3, ETS1, S100A10, ADAMTS17, KCNH5, ARHGAP6, KCNMA1, MAP7, KCNN2 |
| LEF1 | 59 | 2.10 × 10−8 | PDCD10, NRXN1, SLIT3, RORA, YWHAZ, COX7B, SYNPR, SCN3A, SORCS1, TMSB4X, ADAMTSL1, NXN, CLSTN2, ZNF8, CNTN6, MAGED2, WHSC1L1, GMPR2, PDE4D, ABCF2, RARB, CNKSR2, TIA1, SMARCA1, SFRP2, OPCML, WDFY3, MBTD1, CACNA1E, PTPRO, MCTS1, DMD, KLF12, CTNND1, SGCD, ACACA, POGK, OXCT1, TAF1, PAX3, SLC6A5, SOX5, 1, SIX4, GPC6, DLC1, GTF2A2, TLE3, GAB2, TMSL3, CACNA2D3, ETS1, BZW1, ADAMTS12, CD160, TCERG1L, KCNH5, ARHGAP6, NR2F1 |
| MAZ | 51 | 4.07 × 10−8 | PDCD10, SLIT3, SV2B, RORA, YWHAZ, CNTNAP2, SORCS1, PRKCI, CTNND2, ACCN2, ESR1, MAGED2, HRK, FKBP2, RARB, CNKSR2, SSR1, SMARCA1, SFRP2, PRKD2, UBE2L3, PTPRF, ID3, DMD, ITM2C, KLF12, P4HA1, BCOR, RGS7, CTNND1, DUSP6, POGK, TAF1, LYPLA2, AUTS2, DLG2, SOX5, SIX4, DLC1, TLE3, PRDM16, NGFRAP1, POLR1D, ARVCF, BZW1, THRAP3, TRRAP, ZNRF1, KCNH5, KCNMA1, NR2F1 |
| OCT1 | 16 | 1.49 × 10−7 | NRXN1, NR2C2, SCN3A, PDE4D, RARB, DMD, KLF12, DUSP6, SOX5, DLC1, TLE3, GAB2, TMSL3, TCERG1L, IRX2, NR2F1 |
| MEF2 | 27 | 2.32 × 10−7 | HIPK1, CTNNA1, NRXN3, ESR1, PPM1B, SLC12A1, SMARCA1, OPCML, WBP5, ADCY2, CUL3, DMD, KLF12, P4HA1, CTNND1, SGCD, DLG2, SOX5, GLG1, NELL2, GRM8, CACNA2D3, ETS1, CIAO1, ADAMTS12, AGTPBP1, NR2F1 |
FDR-corrected p-values from the hypergeometric test are shown in the table.