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Schematic presentation showing the effect of miR-133a on prevention of cardiac fibrosis and cardiomyopathy in the diabetic heart. In the diabetic Akita heart, cardiac miR-133a is downregulated but cardiac fibrosis, hypertrophy, and diabetic cardiomyopathy (DMCM) were increased. However, transgenic expression of miR-133a in the diabetic Akita heart increases the levels of miR-133a and consequently decreases cardiac fibrosis, hypertrophy, and DMCM.
