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. 2019 Apr 24;10:691. doi: 10.3389/fmicb.2019.00691

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Copyright © 2019 Zhang, Li, Lv, Yan, Wang and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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VT-1161 andVT-1598 forming the H bond. VT-1161 and VT-1598 forming the H bond with the His377 of C. albicans CYP51 and the His374 of A. fumigates CYP51B. (A) C. albicans CYP51-His377-VT-1161(5TZ1); (B) A. fumigates CYP51B-His374-VT-1598 (5FRB). They are obtained from the published crystal data file from the PDB database, and then displayed by PyMOL Version 1.5.0.3. The red dot line means H-bonds formed between VT-1161 and C. albicans CYP51-His377 in Figure 5A, and H-bonds formed between VT-1598 and A. fumigates CYP51B-His374 in Figure 5B.