Figure 2.

Short-term hTDP-43-WT suppression prevents installment of working/spatial memory deficits. (A–C) Y-maze spontaneous alternation task. (A) Scheme of the Y-maze. (B,C) Mice were allowed to explore the maze freely for 8 min without training, reward, or punishment. Alternation behavior (defined as a consecutive entrances into each of the three arms without repetition) and total arms entries, as an index of locomotion activity, were quantified. (B) 0.5 month mice Y-maze performance (n = 12, 11 for control and bigenic 0.5 month mice, respectively). (C) 1 month (sup) mice performance (n = 12, 10 for control and bigenic 1 month (sup) mice, respectively).