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. 2019 Apr 24;10:369. doi: 10.3389/fgene.2019.00369

Figure 3.

Figure 3

tTA/WT12 mice display early sociability deficits, which persist after transgene suppression. (A) Scheme of three-chamber social interaction apparatus, a rectangular box made of a black Plexiglass divided in three interconnected chambers. Social behavior was analyzed at 0.5 months off Dox (0.5 month mice) (B–E), and after 2 weeks of Dox transgene suppression treatment [1 month (sup)] (F–I). (B,F) The time spent sniffing the social (S; P21–P28 male mouse) or the non-social (NS; black plastic object) stimulus during a 10 min session (test phase) was recorded. (C,G) Mean sniffing time per contact. (D,H) Number of social contacts. (E,I) Total entries in each chamber. *p < 0.05, **p < 0.01, ***p < 0.001, two-way RM-ANOVA/Newman-Keuls post hoc test, except for (G), significance of main effects. n = 11, 15 for control and bigenic 0.5 month mice, respectively; n = 10, 13 for control and bigenic 1 month (sup) mice, respectively. n.s., not significant. Data represent mean ± SEM.