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. 2019 Apr 24;7:59. doi: 10.3389/fcell.2019.00059

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Copyright © 2019 Fritzsch, Elliott, Pavlinkova, Duncan, Hansen and Kersigo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic depiction of migration defects with projection changes in the CNS (A,B) and PNS (C,D). Deletion of (Prk1-/-) results in aberrant migration (B) of Facial Branchial Motor neurons (FBM) which migrate more like the olivo-cochlear efferents (OCE) in control mice (A) instead along the floor plate (FP) from rhombomere 4 (r4) to r6 (A). 1,2,3 indicates different migratory positions, dotted line indicates leading process. Neither crossing of the floor plate by efferents (red fiber in A,B) nor peripheral projections seem to be affected. In contrast, in the PNS the unusual migration of some spiral ganglion neurons into the vestibular ganglion (green, red) in Neurod1 cKO mice (D) results in aberrant connections of spiral ganglion neurons (green and red cells in D) to vestibular sensory epithelia (AC, anterior crista; AN, auditory nerve; AVN, auditory-vestibular nerve; HC, horizontal crista; PC, posterior crista; S, saccule; U, utricle). Modified after (Yang et al., 2014a; Macova et al., 2019).