Table 1.

PI3Kα inhibitory activity and anti-proliferative activity of compounds 8a-o and 10.

Compd.	R	PI3Kα IC50 (nM)	GI50 (μM)
			PC3	HCT116
10	–	14.28	7.16	3.67
8a		0.63	1.90	0.70
8b		2.03	0.84	1.13
8c		0.67	0.45	0.96
8d		1.03	1.87	1.56
8e		1.43	1.48	1.25
8f		0.62	0.95	1.46
8g		0.68	2.50	1.30
8h		0.53	0.36	0.51
8i		0.50	0.40	0.47
8j		1.90	0.88	0.97
8k		0.79	0.28	0.32
8l		0.75	1.31	1.56
8m		0.68	2.56	1.29
8n		1.10	1.43	1.79
8o		1.80	4.83	1.52
GSK2126458	-	0.30	0.22	0.18