Table 2.

Enzymatic activity of compounds 8c and 8i against PI3Ks and mTOR.

Compd.	IC50 (nM)
	PI3Kα	PI3Kβ	PI3Kγ	PI3Kδ	mTOR
8c	0.67	1.2	0.50	1.3	1.2
8i	0.50	1.5	0.55	1.0	1.3
GSK2126458	0.30	0.19	0.44	0.78	0.34