Table 3.

The in vitro metabolic stability of compound 8i in HLM and RLM.

Compd.	HLM				RLM
	T1/2 (min)	CLint(mic) (μL/min/mg)a	CLint(liver) (mL/min/kg)b	Remaining% (T = 60min)	T1/2 (min)	CLint(mic) (μL/min/mg)a	CLint(liver) (mL/min/kg)b	Remaining% (T = 60min)
8i	74.9	18.5	16.6	57.1	>145	< 9.6	< 17.3	72.8
Testosterone	13.7	101.2	91.1	4.8	0.7	2097.5	3775.6	0.0
Diclofenac	9.6	144.3	129.9	1.2	17.4	79.5	143.0	8.7
Propafenone	6.6	211.1	190.0	0.2	2.1	657.9	1184.2	0.3

^aCL_int(mic) = 0.693/half life/mg microsome protein per mL.

^bCL_int(liver) = ${\text{CL}}_{\text{int}(\text{mic})}^{*}$mg microsomal protein/g liver weight^*g liver weight/kg body weight.