Table 1.

Effects on body weight, total food intake and liver triglyceride.

	CH-Con	MCD-Con	MCD-Mtr	MCD-Met
Body weight (g)	24.3 ± 0.2	23.5 ± 0.2∗∗	22.6 ± 0.1††	22.7 ± 0.1††
Body weight gain (g)	2.0 ± 0.2	0.4 ± 0.2∗∗	0.3 ± 0.2	0.7 ± 0.1
Caloric intake (kcal/kg.day)	268 ± 8	314 ± 9	320 ± 10	335 ± 18
Fasting blood glucose (mM)	8.0 ± 0.5	7.4 ± 0.4	6.3 ± 0.4	6.4 ± 0.5
Liver triglyceride (μmol/g)	13.8 ± 4.2	31.6 ± 3.3∗∗	28.2 ± 2.5	31.2 ± 3.1

Mice were fed a chow (CH-Con), or MCD alone (MCD-Con), MCD-treated with matrine (MCD-Mtr; 100 mg/kg/day) or MCD-treated with metformin (MCD-Met; 250 mg/kg/day). Body weight and food intake were measured twice a week. Blood glucose was performed at week 5. Plasma was collected before tissue collection at week 6 for the subsequent analysis for ALT and AST. ^∗∗p < 0.01 vs. CH-Con; ^††p < 0.01 vs. MCD-Con (n = 8 mice/group).