FIGURE 1.

Hierarchical clustering analysis of reconstructed metabolic networks of gut microbiota of infants at 1 week and 1, 3, 7 months, and 1 year of age. Distances based on active reactions (A), metabolites (B) and functional metagenomic annotations (C). In (A), for each time point, we defined a binary vector that stores active reactions in its reconstruction. We compared these binary vectors for the different time points using Jaccard’s distance. A similar analysis was done for metabolites in (B). For functional metagenomic annotation data in (C), we used Euclidean distance.