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. 2019 Apr 24;13:162. doi: 10.3389/fncel.2019.00162

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Copyright © 2019 Falomir-Lockhart, Cavazzutti, Giménez and Toscani.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic mechanism proposed for integration of the FAs Receptors System. Alternative FAs receptors are shown along with their demonstrated or putative interactions and their better characterized cellular effects. FFAR: Free Fatty Acid Receptor; FABP: Fatty Acid Binding Protein; PPAR: Peroxisome Proliferator-Activated Receptor; RXR: Retinoid X Receptor; FA: Fatty Acid; PPRE: PPAR Response Element. AC: Adenylate Cyclase; DAG: Diacylglycerol; FATP: FAT/CD36: Fatty Acid Translocase; Fatty Acid Transport Protein; IP3: Inositol (1,4,5)-Trisphosphate; IP₃R: Inositol trisphosphate Receptor; PI3K: Phosphatidyl Inositol (3,4,5)-Trisphosphate Kinase; PLA2: Phospholipase A2; PLC: Phospholipase C; PKA: Protein Kinase A; PKAB/Akt: Protein Kinase B; PKC: Protein Kinase C.