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. 2019 Apr 24;10:869. doi: 10.3389/fmicb.2019.00869

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Copyright © 2019 Roberts, Powell, Pritchard, Thomas and Jenkins.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Viability of three P. aeruginosa Reference Panel (PaRP) isolates; #1, #17, and #28, grown in ex vivo Porcine Lung (EVPL) bronchiolar tissue for 24 h and treated with ASM or clinically relevant antibiotics (Cip; Ciprofloxacin, Tob; Tobramycin, and Caz; Ceftazidime) supplemented with 32% and 64% (w/v) manuka honey for 16 h. Dashed horizontal lines indicate the detection level of the model. Error bars denote Standard Deviation. Varying levels of statistical significance denoted by ^∗, ^∗∗, and ^∗∗∗ (P≤0.05, 0.001, and 0.0001 respectively).