Table 4.
Clinical observations.
| Observations | Sex | TREATMENT |
||||
|---|---|---|---|---|---|---|
| Group 1 |
Group 2 |
Group 3 |
Group 4 |
Group 5 |
||
| 0.9% NaCl | GLA-SE | PRIMVAC | PRIMVAC + Alhydrogel® | PRIMVAC + GLA-SE | ||
| Observation period: Days 1–45 (early and late sacrifice animals) | ||||||
| Thin appearance | M | – | – | – | – | – |
| F | – | – | – | 1/15(7%) | – | |
| Hunched posture | M | – | – | – | – | |
| F | – | – | – | 1/15 (7%) | – | |
| Thinning of hair | M | – | – | – | – | |
| F | 2/15 (13%) | – | – | – | 2/15 (13%) | |
| Shortened tail | M | 1/16 (6%) | – | – | – | – |
| F | – | – | – | – | – | |
| Alopecia/right forelimb | M | 3/16 (19%) | 1/15 (7%) | 1/15 (7%) | – | 1/15 (7%) |
| F | 2/15 (13%) | – | – | – | – | |
| Alopecia/left forelimb | M | 3/16 (19%) | 1/15 (7%) | – | – | 1/15 (7%) |
| F | 2/13 (13%) | – | – | |||
| Scabs | M | 1/16 (6%)1 | – | – | – | – |
| F | – | 1/15 (7%)2 | 1/15 (7%)3 | – | – | |
| Eye opacity | M | 1/16 (6%)5 | – | – | – | – |
| F | – | – | – | – | – | |
| Chromo-rhynorrhea | M | – | 1/15 (7%) | – | – | 1/15 (7%) |
| F | – | – | 1/15 (7%) | – | – | |
| Soiled coat | M | 1/16 (6%) | – | – | – | – |
| F | – | – | – | – | – | |
| Observation period: Days 45–65 (late sacrifice animals only) | ||||||
| Thinning of hair | M | – | 1/5 (20%) | – | – | – |
| F | – | – | – | – | 2/5 (40%) | |
| Alopecia/right forelimb | M | – | – | – | – | – |
| F | 1/5 (20%) | – | – | – | – | |
| Alopecia/left forelimb | M | – | – | – | – | – |
| F | 1/5 (20%) | – | – | 1/5 (20%) | – | |
| Scabs | M | – | 1/5 (20%) | – | – | – |
| F | – | – | – | – | – | |
| Eye opacity | M | 1/5 (20%)5 | – | – | – | – |
| F | – | – | – | – | – | |
Location of scabs: 1 on tongue, 2 on tail, 3 on neck - dorsal region, 4 back - thoracic region.
Eye opacity: 5 left eye only.
– = not observed.