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Combined treatment with crizotinib and either CsA or PD98059 does not increase systemic toxicity in xenograft models. (a) Body weight of nude mice in each group. (b) Serum glutamic-pyruvic transaminase (ALT), glutamic-oxaloacetic transaminase (AST) and creatinine (SCr) levels were determined after the nude mice had been sacrificed.
