Table 2.

The association of individual SNPs with metabolites

Phenotype	Chromosome	Position	SNP	Effect allele	Other allele	EAF	Beta	SE	p‐value1	R2	F‐stat	N
Acetate	6	12,042,473	rs6933521	C	T	0.12	−0.092	0.016	8.10E‐09	0.0017	44.3	24,742
Pyruvate	2	27,730,940	rs1260326	C	T	0.64	−0.081	0.010	5.47E‐16	0.0030	59.4	22,529
Pyruvate	16	69,979,271	rs74249229	T	C	0.05	−0.153	0.023	2.13E‐11	0.0022		23,561
Valine	2	65,208,074	rs10211524	A	G	0.41	0.086	0.009	5.24E‐20	0.0036	79.0	24,898
Valine	4	89,206,230	rs9637599	C	A	0.47	0.114	0.009	1.67E‐35	0.0064		24,899
Valine	11	116,661,826	rs2072560	C	T	0.93	0.105	0.018	3.28E‐09	0.0014		24,895
Valine	17	7,063,667	rs7406661	C	T	0.24	0.079	0.013	5.35E‐10	0.0023		22,659
DHA	11	116,651,115	rs11604424	T	C	0.76	−0.083	0.018	7.84e‐09	0.0025	41.7	13,495
DHA	19	19,667,254	rs143988316	T	C	0.07	−0.150	0.026	1.10e‐09	0.0029		13,494
DHA	6	10,990,493	rs2281591	G	A	0.13	−0.108	0.003	3.66e‐09	0.0026		13,498
DHA	15	58,726,744	rs261334	C	G	0.77	−0.110	−0.020	1.44e‐13	0.0043		13,498
Glycine	2	210,439,980	rs147007805	A	T	0.07	−0.140	0.024	8.05E‐09	0.0027	444.6	18,732
Glycine	2	211,540,507	rs1047891	A	C	0.33	0.487	0.011	1.00E‐200	0.1055		18,730
Glycine	3	125,909,669	rs1992855	C	T	0.41	0.062	0.011	5.60E‐09	0.0019		18,733
Glycine	8	9,181,395	rs2169387	G	A	0.87	−0.130	0.016	1.31E‐16	0.0039		18,729
Glycine	9	5,934,989	rs13298772	C	T	0.05	0.273	0.023	3.74E‐33	0.0075		18,732
Glycine	16	81,065,282	rs10083777	T	C	0.17	−0.106	0.015	2.97E‐13	0.0032		18,732

¹ Obtained from linear regression of exposure (metabolic trait) on instrument.

SNP, single nucleotide polymorphism; EAF, effect allele frequency; SE, standard error; N, sample size; DHA, docosahexaenoic acid.