Table 2.
Phenotype | Chromosome | Position | SNP | Effect allele | Other allele | EAF | Beta | SE | p‐value1 | R2 | F‐stat | N |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Acetate | 6 | 12,042,473 | rs6933521 | C | T | 0.12 | −0.092 | 0.016 | 8.10E‐09 | 0.0017 | 44.3 | 24,742 |
Pyruvate | 2 | 27,730,940 | rs1260326 | C | T | 0.64 | −0.081 | 0.010 | 5.47E‐16 | 0.0030 | 59.4 | 22,529 |
Pyruvate | 16 | 69,979,271 | rs74249229 | T | C | 0.05 | −0.153 | 0.023 | 2.13E‐11 | 0.0022 | 23,561 | |
Valine | 2 | 65,208,074 | rs10211524 | A | G | 0.41 | 0.086 | 0.009 | 5.24E‐20 | 0.0036 | 79.0 | 24,898 |
Valine | 4 | 89,206,230 | rs9637599 | C | A | 0.47 | 0.114 | 0.009 | 1.67E‐35 | 0.0064 | 24,899 | |
Valine | 11 | 116,661,826 | rs2072560 | C | T | 0.93 | 0.105 | 0.018 | 3.28E‐09 | 0.0014 | 24,895 | |
Valine | 17 | 7,063,667 | rs7406661 | C | T | 0.24 | 0.079 | 0.013 | 5.35E‐10 | 0.0023 | 22,659 | |
DHA | 11 | 116,651,115 | rs11604424 | T | C | 0.76 | −0.083 | 0.018 | 7.84e‐09 | 0.0025 | 41.7 | 13,495 |
DHA | 19 | 19,667,254 | rs143988316 | T | C | 0.07 | −0.150 | 0.026 | 1.10e‐09 | 0.0029 | 13,494 | |
DHA | 6 | 10,990,493 | rs2281591 | G | A | 0.13 | −0.108 | 0.003 | 3.66e‐09 | 0.0026 | 13,498 | |
DHA | 15 | 58,726,744 | rs261334 | C | G | 0.77 | −0.110 | −0.020 | 1.44e‐13 | 0.0043 | 13,498 | |
Glycine | 2 | 210,439,980 | rs147007805 | A | T | 0.07 | −0.140 | 0.024 | 8.05E‐09 | 0.0027 | 444.6 | 18,732 |
Glycine | 2 | 211,540,507 | rs1047891 | A | C | 0.33 | 0.487 | 0.011 | 1.00E‐200 | 0.1055 | 18,730 | |
Glycine | 3 | 125,909,669 | rs1992855 | C | T | 0.41 | 0.062 | 0.011 | 5.60E‐09 | 0.0019 | 18,733 | |
Glycine | 8 | 9,181,395 | rs2169387 | G | A | 0.87 | −0.130 | 0.016 | 1.31E‐16 | 0.0039 | 18,729 | |
Glycine | 9 | 5,934,989 | rs13298772 | C | T | 0.05 | 0.273 | 0.023 | 3.74E‐33 | 0.0075 | 18,732 | |
Glycine | 16 | 81,065,282 | rs10083777 | T | C | 0.17 | −0.106 | 0.015 | 2.97E‐13 | 0.0032 | 18,732 |
Obtained from linear regression of exposure (metabolic trait) on instrument.
SNP, single nucleotide polymorphism; EAF, effect allele frequency; SE, standard error; N, sample size; DHA, docosahexaenoic acid.