Figure 5:

Dexamethasone entry derived by simulations of the data viewed from three perspectives. (a) Absolute entry shows the total amount (in ng) entering at the round window (blue), apex (yellow) and stapes (red) for the 4 experimental conditions of the study. The amount was substantially higher for dexamethasone-phosphate (Dex-P) liquid solution than for all other conditions. (b) When normalized by the applied concentration entry was far higher for dexamethasone (Dex) than dexamethasone-phosphate. (c) Normalizing each condition to the total amount entering allowed the three sites of entry to be best compared. Entry at the stapes appeared to be notably lower when dexamethasone-phosphate was applied in gel.