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. 2018 Nov 5;40(17):1362–1373. doi: 10.1093/eurheartj/ehy696

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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2018. For permissions, please email: journals.permissions@oup.com.

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Blockade of Lpar1 decreased platelet-mediated fibrosis. (A) Trichrome Masson analysis of mouse leaflets demonstrating that Ki16425 decreases the level of fibrotic tissues in aortic valves of mice injected with platelets (n = 22). Scale bar: 100 µM. (B) Proposed working model. ADP, adenosine diphosphate; ALP, alkaline phosphatase; ATX, autotaxin; BGLAP, bone gamma-carboxyglutamic acid-containing protein; BMP2, bone morphogenetic protein 2; GPIIb/IIIa, glycoprotein IIb/IIIa; LPAR1, lysophosphatidic acid receptor 1; lysoPC, lysophosphatidylcholine; LysoPA, lysophosphatidic acid; PLA1, phospholipase A1; P2RY12, purinergic receptor P2Y1; RGDS: arginyl-glycyl-α-aspartyl-serinyl; RUNX2, Runt-related transcription factor 2; VICs: valvular interstitial cells.