Table 4.

S5 scores, HPV genotype(s), HPV viral load and LBC results for women who developed invasive cervical cancers

Study Arm	Baseline sample				Subsequent sample			Cancer type	Age at cancer diagnosis
	Months prior to cancer diagnosis	HPV Typea/LBC Result	S5 Score	Viral loadb	Months prior to cancer diagnosis	HPV Type(s)a/LBC Result	S5 Score
CA	67	HPV16/NILM	5.8	404.25				Squamous large cell non‐keratinizing	62
SA	4	HPV18/ASCH	11.3	65.47				Adenocarcinoma	41
CA	25	NT/NILM	5.0	16.31	1	HPV18/ ATYENNEO	9.4	Adenocarcinoma	48
CA	6	HPV18/LSIL	1.7	2.20				Adenocarcinoma	35
CA	40	NT/NILM	2.9	0.64	6	HPV18/ASCH	12.4	Adenocarcinoma	33
CA	34	NT/NILM	5.8	124.91	5	HPV16, HPV84/ ATYEMET	18.5	Adenocarcinoma	44
SA	7	HPV16/NILM	10.6	125.78				Adenocarcinoma	28
CA	30	NT/NILM	7.3	0.20	2	HPV18/HSIL	27.0	Squamous large cell non‐keratinizing	50

LBC, liquid‐based cytology; CA, control arm; SA, safety arm; NT, not tested; NILM, negative for intraepithelial lesions and malignancy; ASCH, atypical squamous cells, cannot rule out high‐grade; ATYENNEO, atypical endocervical cells, favour neoplastic; LSIL, low‐grade squamous intraepithelial lesion; ATYEMET, atypical endometrial cells; HSIL, high‐grade squamous intraepithelial lesion

^aHPV16 and 18 were identified by the cobas 4800 HPV test; other HPV types were identified by the Linear Array HPV Genotyping test.

^bHybrid capture 2 relative light unit/cutoff ratios were used as a surrogate for HPV viral load, where the threshold for a positive test was ≥1.0; higher ratios indicate a higher viral load.