Figure 3.

Rat MOv18 IgE and IgG induce comparable mild toxicities only. A, Percentage of rats in each treatment group experiencing the 3 detected toxicities (piloerection, hunching and reduced activity). B, Percentage of animals within each treatment group to experience 1, 2 or 3 toxicities. C, Histopathological evaluations of tissues 30 days after administration of two doses (every 14 days) of rMOv18 IgE or IgG2b at 5 mg/kg and 50 mg/kg or PBS rats (n = 10 per group). Sections were stained with H&E and observed at brain = 25 × magnification; colon, kidney, liver, mesenteric lymph nodes (LN), tail and thymus = 50 × magnification; spleen = 100 × magnification [Colour figure can be viewed at wileyonlinelibrary.com]