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. 2018 Oct 8;73(12):2328–2341. doi: 10.1111/all.13455

Figure 4.

Figure 4

Absence of rMOv18 IgE‐associated changes in body weight or blood haematological or biochemical parameters. A, Weekly weights of rats following weekly treatment with rMOv18 IgE at 1 mg/kg (n = 10), 10 mg/kg (n = 10) and 50 mg/kg (n = 10) or PBS (n = 10). B‐E, Blood biochemical and haematological parameters were measured immediately before necropsy on day 30 following 4 weekly doses of rMOv18 IgE at 1 mg/kg (n = 10), 10 mg/kg (n = 10) and 50 mg/kg (n = 10) or PBS (n = 10). Dotted lines indicate normal range values for each parameter determined in healthy Wistar Albino Glaxo (WAG)/RijCrl.24 F‐G, Rat anti‐human folate receptor α (FRα) antibodies and rat antidrug antibodies (ADA) measured in rat serum following weekly treatment with PBS, or rMOv18 IgE at 1 mg/kg, 10 mg/kg and 50 mg/kg (n = 10 per group) [Colour figure can be viewed at wileyonlinelibrary.com]