Figure 1.

Global and specific regulation of translation initiation. (a) Overview of the major steps (numbered) in the cap‐dependent translation initiation pathway in Saccharomyces cerevisiae. (b) Global mechanisms for translational repression in response to different stresses. Mechanisms that interfere with the initiation pathway are shown in red. (c) Overview of mechanisms that promote translational upregulation or maintenance of specific mRNAs contrary to global stress‐induced repression (shown in green). Note that the elements and mechanisms shown may also combine to influence translation negatively, depending on their context [Colour figure can be viewed at wileyonlinelibrary.com]