Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Mapping the sites of covalent modification via LC‐MS/MS. BTZ (2) was docked within the binding site of BRD4(1) (left) and then superimposed to the same pocket in BRD3(2) (right). Two lysines, K91 and K336, were found to be near the reactive dichlorotriazine warhead, thus suggesting they would be the expected site of covalent interaction. The predictions made by docking were subsequently confirmed by LC‐MS/MS peptide mapping.
