Table 1.

Lewy body presence or absence in PD patients with PARKIN mutations

Sex	Age of onset	Age of death	PARKIN alleles	Lewy bodies?	Distribution of neuronal loss	Notes	References
F	NA	67	PARK2	No	Substantia nigra, locus coeruleus	Japanese, Family 556	Takahashi et al. (1994)
			PARK2
F	20	52	PARK2	No	Substantia nigra	Japanese, Family M, patient M‐2, no dementia	Yamamura et al. (1998)
			PARK2
M	24	62	Exon 4: deletion	No	Substantia nigra, locus coeruleus	Japanese, neurofibrillary tangles present	Mori et al. (1998)
			Exon 4: deletion
M	32	70	Exon 4: deletion	No	Substantia nigra, locus coeruleus	Japanese, patient III‐4, no evidence of dementia	Hayashi et al. (2000)
			Exon 4: deletion
M	18	75	Exon 3: deletion	No	Substantia nigra	Dutch, patient II‐3, tau pathology	van de Warrenburg et al. (2001)
			Exon 6: Lys211Asn
M	34	47	Exon 2: 2‐bp deletion	No	Substantia nigra, locus coeruleus	Tunisian, patient IV‐I	Gouider‐Khouja et al. (2003)
			Exon 2: 2‐bp deletion
F	36	86	Exon 6: deletion	No	Substantia nigra	British, no evidence of dementia	Doherty et al. (2013)
			Exon 7: Arg275Trp
F	25	62	Exon 3: 40‐bp deletion	No	Substantia nigra	British, no evidence of dementia	Doherty et al. (2013)
			Exon 7: Arg275Trp
M	32	68	Exon 3: 40‐bp deletion	No	Substantia nigra, locus coeruleus	Irish, no evidence of dementia	Doherty et al. (2013)
			Exon 12: Gly430Asp
M	16	60	Intron 5: IVS5‐1G>A	No	Substantia nigra	Peruvian, patient II‐2	Cornejo‐Olivas et al. (2015)
			Exon 7: deletion
M	20	79	Exon 3–4: deletion	No	Substantia nigra	Norwegian, no evidence of dementia	Johansen, Torp, Farrer, Gustavsson, and Aasly (2018)
			Exon 3–4: deletion
M	41	52	Exon 3: 40‐bp deletion	Yes	Substantia nigra, locus coeruleus	North American, patient Pw3	Farrer et al. (2001)
			Exon 7: Arg275Trp
F	33	70	Exon 3: deletion	Yes	Substantia nigra, locus coeruleus	Japanese, young onset, LBs in pedunculopontine nucleus	Sasaki et al. (2004)
			Exon 3: deletion
M	49	73	Exon 7: deletion	Yes	Substantia nigra, locus coeruleus	Italian, patient IV.33, late onset	Pramstaller et al. (2005)
			Exon 9: 1‐bp deletion
F	33	60	Exon 7: Arg275Trp	Yes	Substantia nigra, locus coeruleus	Irish, young onset, sparse cortical LBs	Doherty et al. (2013)
			Exon 12: Gly430Asp
M	46	82	Exon 6: deletion	Yes	Substantia nigra, brain stem	British, no evidence of dementia, brain stem LBs	Doherty et al. (2013)
			Exon 7: Arg275Trp
F	61	72	Exon 2–4: deletion	Yes	SN, LC, dorsal motor nucleus of the vagus, basal nucleus of Meynert	Japanese, late onset, no orthostatic hypotension or dementia	Miyakawa et al. (2013)
			Exon 2–4: deletion

LBs: Lewy bodies; SN: substantia nigra; LC: locus coeruleus.