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. 2018 Nov 8;60(2):134–144. doi: 10.1002/em.22254

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© 2018 The Authors. Environmental and Molecular Mutagenesis published by Wiley Periodicals, Inc. on behalf of Environmental Mutagen Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Induction of MN after treatment of Huh6 cells with different direct (A–D) and indirect (E–I) acting mutagens for different time periods. CDDP, H₂O₂, MMS, and NDMA were dissolved in medium, Etop, AFB1, B(a)P, IQ, and PhiP were dissolved in DMSO. Bars show means ± SD of results obtained in a representative experiment. Two cultures were treated per experimental point and from each, at least 1,000 BNC cells were evaluated. Data were evaluated by generalized linear model with Poisson counts. Chi‐square tests for overdispersion were applied. Stars indicate statistical significance (P ≤ 0.05).