Table 2.

Number of Anomalies per 1,000 Binucleated Cells and 95% Confidence Intervals Estimated by Poisson Regression^a

Endpoint	Condition	n/1,000	95% CI		SE	P value	4 hr	24 hr	24 hr (10%)	48 hr
MNib	4 hr	16.00	13.45	19.03	1.41	0.678	‐	0.482	0.711	0.567
	24 hr	14.63	12.20	17.53	1.35		0.482	‐	0.283	0.896
	24 hr (10%)	16.75	14.14	19.84	1.45		0.711	0.283	‐	0.346
	48 hr	14.88	12.43	17.80	1.36		0.567	0.896	0.346	‐
Total MNic	4 hr	16.75	14.14	19.84	1.45	0.549	‐	0.806	0.373	0.665
	24 hr	16.25	13.68	19.30	1.43		0.806	‐	0.255	0.852
	24 hr (10%)	18.63	15.86	21.87	1.53		0.373	0.255	‐	0.185
	48 hr	15.88	13.34	18.89	1.41		0.665	0.852	0.185	‐
NBuds	4 hr	13.25	10.95	16.03	1.29	0.001d	‐	0.575	0.002d	0.081
	24 hr	12.25	10.05	14.93	1.24		0.575	‐	<0.001d	0.021d
	24 hr (10%)	19.50	16.67	22.81	1.56		0.002d	<0.001d	‐	0.176
	48 hr	16.63	14.03	19.70	1.44		0.081	0.021d	0.176	‐
NB	4 hr	0.25	0.06	1.00	0.18	0.938	‐	1.000	1.000	0.564
	24 hr	0.25	0.06	1.00	0.18		1.000	‐	1.000	0.564
	24 hr (10%)	0.25	0.06	1.00	0.18		1.000	1.000	‐	0.564
	48 hr	0.13	0.02	0.89	0.13		0.564	0.564	0.564	‐

^aStandard error from 4 experiments with duplicate counts.

^bMNi – number of micronucleated cells in 1,000 binucleated cells.

^cTotal number of micronuclei in 1,000 binucleated cells. P value for comparison of all conditions and from individual comparisons.

^dData were evaluated by generalized linear model with Poisson counts. Chi‐square tests for overdispersion were applied. Stars indicate statistical significance (P ≤ 0.05).