Adjusted mean (SEM) percentage change of radiolabeled global efflux in response to exercise training in STRRIDE-PD (a) and of non-ABCA1 efflux in E-MECHANIC (b). Values adjusted for age, sex, race, baseline BMI, and baseline value. ABCA1, ATP binding cassette transporter A1. aP=0.005 and bP<0.05 for difference from High-Vig. cP=0.01 for difference from control group. Modified from [12■■].