Table 3.
Hazard ratios of all‐cause mortality related to clozapine use in patients with treatment‐resistant schizophrenia
| Deaths/total N | HRs (95% CIs) | P | |
|---|---|---|---|
| Crude | 110/2837 | 0.73 (0.49–1.08) | 0.12 |
| Multivariate Cox proportional hazard models adjusted for | |||
| Sociodemographic variables | 110/2837 | 0.60 (0.40–0.92) | 0.02 |
| Plus history of substance use disorders | 110/2837 | 0.61 (0.40–0.93) | 0.02 |
| Plus clinical monitoring | 110/2837 | 0.67 (0.43–1.03) | 0.07 |
| Plus mental health symptom severity | 108/2788 | 0.71 (0.46–1.11) | 0.14 |
| Plus additional mental and physical health problems | 108/2783 | 0.66 (0.42–1.03) | 0.07 |
| Plus functional status | 104/2720 | 0.61 (0.38–0.97) | 0.04 |
HR, hazard ratio; 95% CI, 95% confidence interval.