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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Mov Disord. 2018 Nov 15;33(12):1928–1937. doi: 10.1002/mds.27541

FIG. 1.

FIG. 1.

As age increases, somatodendritic morphology in dopamine neurons from MitoPark mice becomes disrupted. Substantia nigra dopamine neurons from 12-week-old MitoPark mice (A2) exhibited a similar appearance to neurons from littermate controls (A1). In contrast, the number of branches appeared to be reduced in 16–20-week old MitoPark mice (B2 vs B1). Furthermore, branch number and length as well as soma size were dramatically reduced in 27- to 31-week-old MitoPark mice (C2 vs C1). Neurons from control mice exhibited consistent morphology throughout all age groups.