Table 2.
Summarized diagnostic factors of the individual miRNAs, combined miRNA panels and serum NGAL for AKI
| Variate | Value (mean ± SE) | Fold-change (AMI+AKI+/AMI+AKI−) | P (MWU test) | Cut-off | AUC (95% CI) | Sensitivity (%) | Specificity (%) | |
|---|---|---|---|---|---|---|---|---|
| AMI+AKI− | AMI+AKI+ | |||||||
| miR-24 (Ct) | 13.64 ± 0.26 | 11.74 ± 0.31 | 0.27 | < 0.001 | < 12.99 | 0.828 (0.711–0.941) | 82.61 | 69.23 |
| miR-23a (Ct) | 12.23 ± 0.28 | 10.59 ± 0.32 | 0.32 | < 0.001 | < 10.89 | 0.801 (0.676–0.927) | 60.87 | 92.31 |
| miR-145 (Ct) | 9.70 ± 0.31 | 8.16 ± 0.29 | 0.34 | 0.002 | < 9.67 | 0.763 (0.631–0.894) | 86.96 | 53.85 |
| sNGAL (ng/mL) | 64.32 ± 7.50 | 140.13 ± 24.38 | 2.18 | 0.008 | > 87.45 | 0.735 (0.578–0.892) | 63.16 | 84.62 |
| miR-24 + miR-23a (score) | 0.30 ± 0.04 | 0.66 ± 0.06 | 2.16 | < 0.001 | > 0.46 | 0.838 (0.728–0.948) | 73.91 | 80.77 |
| miR-24 + miR-145 (score) | 0.29 ± 0.04 | 0.67 ± 0.06 | 2.27 | < 0.001 | > 0.54 | 0.843 (0.730–0.956) | 69.57 | 88.46 |
| miR-23a + miR-145 (score) | 0.35 ± 0.04 | 0.61 ± 0.05 | 1.74 | < 0.001 | > 0.58 | 0.801 (0.676–0.927) | 60.87 | 92.31 |
| miR-24 + miR-23a + miR-145 (score) | 0.29 ± 0.04 | 0.67 ± 0.06 | 2.29 | < 0.001 | > 0.30 | 0.853 (0.744–0.962) | 95.65 | 65.38 |
AKI cute kidney injury, AMI acute myocardial infarction, AUC area under receiver operating characteristic curve, CI confidence interval, Ct cycle threshold, MWU Mann–Whitney U, NGAL neutrophil gelatinase-associated lipocalin, SE standard error