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. 2019 Apr 30;11:26. doi: 10.1186/s13073-019-0640-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — MS risk gene CD40 expression and signalling in B cells and LCLs. a Risk SNP rs1883832 is a binding site for the EBV transcription factor EBNA2. b The proportion of full length CD40 mRNA is higher in LCLs compared to CD19+ B cells, independent of rs1883832 genotype. c CD40L inhibits LCL proliferation (d) The inhibitory effect of CD40L on LCL proliferation is greater for the protective genotype (CC). Difference in proliferation (Y axis) is the difference in proliferation of LCLs over 5 days cultured with or without CD40L, measured by median fluorescence intensity of cell trace violet. * < 0.05,*** < 0.001, **** < 0.0001