| Methods |
Randomised, double‐blind, placebo‐controlled trial |
| Participants |
20 participants with PROMM (mean age 57.7 ± 8.7 years) |
| Interventions |
Creatine 10 g per day (10 participants) versus placebo (10 participants),
3 months duration |
| Outcomes |
Maximum grip strength
Compound strength score of proximal arm and leg muscles calculated from hand‐held dynamometry
MRC, NSS
Subjective assessment of activity in daily life using a visual analogue scale |
| Notes |
In the creatine group, myalgia improved in two participants and chest pain resolved in another patient |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
A computer random number generator was used |
| Allocation concealment (selection bias) |
Low risk |
Central allocation by hospital pharmacy. Creatine and placebo were filled in coded boxes of identical appearance. Code numbers were broken only at the final data evaluation |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
Blinding of participants and study personnel. Creatine and placebo were administered in an identical powder form |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
No missing outcome data |
| Selective reporting (reporting bias) |
Low risk |
All of the study's pre‐specified outcomes that are of interest in the review have been reported in the pre‐specified way |
| Other bias |
Low risk |
The study appears to be free of other sources of bias |
