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. 2019 Apr 30;11:66. doi: 10.1186/s13148-019-0664-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — EWAS identifies CpG sites significantly associated with ELEE in EPIC-Italy. An EWAS with DNA methylation (HM450K beta values) as outcome and ELEE as exposure was conducted in EPIC-Italy (n = 216) using a beta regression model adjusted for age, BMI, alcohol consumption, and smoking duration (all variables reported at recruitment), and batch, position on batch, and WBC composition. a Manhattan plot of minus log₁₀Q values for FDR-corrected P values from the EWAS of all 404,596 probes across the genome. Blue line indicates FDR Q value threshold of 0.05. b Volcano plot of the regression coefficients (estimates) from the beta regression model, showing significant hypomethylated (in blue) and hypermethylated probes (in purple)