Table 2.
Expression of vitamin D receptor (VDR) on macrophages after two hours of macrophage stimulation
| Factor-by-Group | Vitamin D receptor expression (in relative value units; RVU) | |||||
|---|---|---|---|---|---|---|
| Unadjusted difference in median expression | Adjusted difference in median expressiona | |||||
| β | 95% CI | P-value | β | 95% CI | P-value | |
| LpqH | ||||||
| Uninfected | Ref. | Ref. | Ref. | Ref. | ||
| Latent TB infection | −0.08 | (−2.14, 1.99) | 0.94 | −0.15 | (−2.35, 2.05) | 0.89 |
| Pulmonary TB | 0.20 | (− 0.42, 0.83) | 0.52 | 0.20 | (−0.72, 1.13) | 0.66 |
| Extrapulmonary TB | −0.43 | (−5.34, 4.49) | 0.86 | −0.63 | (−8.29, 7.04) | 0.87 |
| Gamma-irradiated M. tuberculosis | ||||||
| Uninfected | Ref. | Ref. | Ref. | Ref. | ||
| Latent TB infection | 0.96 | (−1.33, 3.26) | 0.40 | 0.48 | (−1.79, 2.75) | 0.67 |
| Pulmonary TB | 0.48 | (−2.61, 3.57) | 0.76 | 0.52 | (− 2.15, 3.18) | 0.70 |
| Extrapulmonary TB | −1.50 | (−5.70, 2.71) | 0.48 | −1.46 | (−6.41, 3.49) | 0.56 |
| M. tuberculosis | ||||||
| Uninfected | Ref. | Ref. | Ref. | Ref. | ||
| Latent TB Infection | −0.04 | (−6.44, 6.36) | 0.99 | −0.09 | (−6.47, 6.30) | 0.98 |
| Pulmonary TB | 0.93 | (−1.04, 2.90) | 0.34 | 0.93 | (−1.66, 3.52) | 0.47 |
| Extrapulmonary TB | 29.22 | (2.36, 56.07) | 0.03** | 29.17 | (5.73, 52.61) | 0.02** |
Unadjusted and adjusted quantile regression analysis of the four study groups according to stimulus used: LpqH, gamma-irradiated M. tuberculosis, and live M. tuberculosis
LpqH: 19kda lipoprotein of M. tuberculosis; Ref.: reference group
Family-wise error rate controlled for multiple comparisons using the Holm-Bonferroni method
aAdjusted for foreign-born status. Holm-corrected P-values significant if < 0.0056; **Significant if using P-values uncorrected for multiple comparisons (p < 0.05)