Table 3.
Median IL-1β production of macrophages assessed 24 h after two hours of stimulation
| Factor-by-Group | Interleukin-1β production (in μg/mL) | |||||
|---|---|---|---|---|---|---|
| Unadjusted difference in median expression | Adjusted difference in median expressiona | |||||
| β | 95% CI | P-value | β | 95% CI | P-value | |
| LpqH | ||||||
| Uninfected | Ref. | Ref. | Ref. | Ref. | ||
| Latent TB infection | −11.95 | (−33.51, 9.61) | 0.27 | −9.62 | (−36.41, 17.16) | 0.47 |
| Pulmonary TB | −8.95 | (−38.11, 20.21) | 0.54 | −8.95 | (−44.03, 26.13) | 0.61 |
| Extrapulmonary TB | 38.88 | (8.45, 69.3) | 0.01** | 44.99 | (−68.86, 158.86) | 0.43 |
| Gamma-irradiated M. tuberculosis | ||||||
| Uninfected | Ref. | Ref. | Ref. | Ref. | ||
| Latent TB infection | −44.28 | (−88.91, 0.36) | 0.05** | −37.92 | (−86.66, 10.81) | 0.12 |
| Pulmonary TB | −12.89 | (−71.47, 45.69) | 0.66 | − 12.89 | (− 101.65, 75.87) | 0.77 |
| Extrapulmonary TB | −16.56 | (−74.34, 41.23) | 0.57 | −16.07 | (− 143.80, 111.66) | 0.80 |
| Live M. tuberculosis | ||||||
| Uninfected | Ref. | Ref. | Ref. | Ref. | ||
| Latent TB infection | −14.07 | (−43.92, 15.79) | 0.35 | −14.07 | (−116.22, 88.08) | 0.78 |
| Pulmonary TB | 160.14 | (−15.26, 335.53) | 0.07 | 160.14 | (−15.87, 336.14) | 0.07 |
| Extrapulmonary TB | 16.71 | (− 131.40, 164.81) | 0.82 | −4.05 | (− 234.47, 226.38) | 0.97 |
Unadjusted and adjusted quantile regression analysis of the four study groups according to stimulus used: LpqH, gamma-irradiated M. tuberculosis, and live M. tuberculosis
LpqH: 19 kDa lipoprotein of M. tuberculosis; Ref.: reference group; Family-wise error rate controlled for multiple comparisons using the Holm-Bonferroni method; aAdjusted for foreign-born status
Holm-corrected P-values significant if < 0.0056; **Significant if using P-values uncorrected for multiple comparisons (p < 0.05)