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. 2019 Apr 24;9:310. doi: 10.3389/fonc.2019.00310

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Copyright © 2019 Tang, Lu, Cui, Zhang, Kong, Liao, Ren, Gong and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clustering dendrogram and determination of soft-thresholding power in the WGCNA. (A) Clustering dendrogram of 302 samples. (B) Analysis of the scale-free fit index for various soft-thresholding powers (β). (C) Analysis of the mean connectivity for various soft-thresholding powers (β). We choose the lowest β that results in approximate scale free topology. (D) Checking the scale free topology when β = 8. The x-axis shows the logarithm of whole network connectivity, y-axis shows the logarithm of the corresponding frequency distribution. On this plot the distribution approximately follows a straight line, which is referred to as approximately scale-free topology.