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. 2019 Apr 24;10:391. doi: 10.3389/fneur.2019.00391

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Copyright © 2019 Melzer, Stark, Keenan, Myall, MacAskill, Pitcher, Livingston, Grenfell, Horne, Young, Pascoe, Almuqbel, Wang, Marsh, Miller, Dalrymple-Alford and Anderson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Associations between cortical amyloid deposition and global cognitive ability and age. (A) Scatter plot showing no evidence of a significant association between global cognitive ability (Cognitive z score) and cortical amyloid (CL; Table 1). (B) Scatter plot of cortical amyloid (CL) vs. age (years). FBB uptake was associated with age (slope = 1.5 CL/year, 95% uncertainty interval [0.6, 2.3], equivalent to SUVR of 0.011/year [0.005, 0.017]). Black line depicts estimate from the Bayesian model fit and the shaded area indicates the 95% credible interval. Color represents cognitive status: green—Parkinson's with normal cognition (PDN), orange—Parkinson's with mild cognitive impairment (PD-MCI), red—Parkinson's with dementia (PDD). CL, centiloid.