3. Sensitivity analysis: blinded versus open‐label studies.

Outcome	All studies effect size (95% CI)	Blinded studies only effect size (95% CI)
Functional class ‐ improvement	2.39 (1.72 to 3.32)+	1.77 (1.24 to 2.52)+
Functional class ‐ worsening	0.88 (0.57 to 1.37)	0.85 (0.54 to 1.35)
Six‐minute walk test distance	19.50 (14.82 to 24.19)+	17.55 (12.82 to 22.29)+
Mortality	0.60 (0.38 to 0.94)+	0.76 (0.45 to 1.29)*
PAP	‐3.60 (‐4.73 to ‐2.48)+	‐2.58 (‐3.86 to ‐1.30)+
PVR	‐2.81 (‐3.80 to ‐1.82)+	‐1.32 (‐2.95 to 0.32)*
Cardiac index	0.31 (0.23 to 0.38)+	0.18 (0.08 to 0.27)+
Cardiac output	0.57 (0.32 to 0.81)+	0.57 (0.32 to 0.81)+
RAP	‐1.90 (‐2.58 to ‐1.22)+	‐1.80 (‐2.55 to ‐1.06)+
Dyspnoea	‐0.21 (‐0.32 to ‐0.11)+	‐0.18 (‐0.29 to ‐0.08)+
Quality of life	0.28 (0.04 to 0.52)+	0.07 (‐0.22 to 0.36)*

⁺Statistically significant; *no longer statistically significant

Abbreviations: CI ‐ confidence interval; PAP ‐ pulmonary arterial pressure; PVR ‐ pulmonary vascular resistance; RAP ‐ right atrial pressure