Keteyian 1996.

Methods	Parallel‐group RCT
Participants	N randomised: 40 (exercise 21, control 19) Diagnosis (% of participants): Aetiology: DCM 40%, IHD 60% NYHA: Class II 67.5%, Class III 32.5% LVEF: 21% (SD 7) Case mix: 100%, as above Age, years: 56 (SD 11) Male: 100% White: 62.5% (remainder black) Inclusion/exclusion criteria: Inclusion: NYHA Class II or III, resting EF < 35% measured by echocardiography or gated equilibrium radionuclide angiography, no change in medical therapy ≥ 30 days before randomisation Exclusion: AF, acute MI 3 months, angina pectoris at rest or induced by exercise, current enrolment in another clinical trial, current participation in a regular exercise programme (at least twice weekly)
Interventions	Exercise: Total duration: 24 weeks Aerobic/resistance/mix: aerobic Frequency: 3 sessions/week (rate of perceived exertion 12 to 14) Duration: 33 minutes Intensity: 60% to 80% peak HR Modality: treadmills, stationary cycles, rowing machines, arm ergometers   Setting: outpatient clinic Other: none reported Control group / Comparison: Usual medical care. Participants were instructed to maintain their normal daily activity habits and not to begin an exercise regimen
Outcomes	Mortality, hospital admissions
Country and setting	North America Single centre
Follow‐up	6 months (after randomisation)
Notes	Study authors were contacted for further details of outcome findings but provided no information. Each participant's physician was asked to not change the drug regimen during the study, if possible Source of funding: Astra Merck
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"Patients were randomly assigned to the exercise group or the control group"
Allocation concealment (selection bias)	Unclear risk	"Each patient's assignment was sealed in an envelope until completion of the second exercise test"
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Not reported
Selective reporting (reporting bias)	Low risk	All outcomes described in the methods were reported in the results
Intention‐to‐treat analysis?	Low risk	"Of the 40 patients entered into the study, only those who also completed the exercise tests at weeks 12 and 24 were considered in the data analysis"
Incomplete outcome data?	Low risk	"Fifteen patients in the exercise group completed the study. Two patients dropped out because of noncardiac medical conditions (progressive, limiting arthritis in one patient and newly diagnosed cancer in the other) that developed within 1 month of the start of the exercise program. One patient developed atrial fibrillation between week 12 and week 24; 3 other patients stopped exercising for personal reasons before week 12 and refused follow‐up testing. Fourteen of the 19 patients in the control group completed the study. Two dropped out for personal reasons and refused follow‐up testing, one developed atrial fibrillation between week 12 and week 24, one was hospitalized at week 22 for an acute myocardial infarction, and one died suddenly"
Groups balanced at baseline?	Low risk	"Among patients who completed the study, no differences in demographic characteristics were seen between the two study groups after randomization"
Groups received same intervention?	Unclear risk	Co‐interventions in the control group were not reported