Fig. 1.

a Mean combined ADA scores (± SEM), rated at children's ages 6 and 11 years by parents and teachers, of over- and not overtreated patients in the period 1–3 months, subdivided into treatment groups OT+/severe, OT+/mild, OT–/severe, and OT–/mild. Difference between ADA scores of OT+ and OT– patients: p < 0.001; difference between severe and mild congenital hypothyroidism (CH) patients in the OT+ group: not significant. b Mean WAST scores (± SEM), rated at ages 6 and 11 by parents and teachers, of under- and not undertreated patients in the period 3–6 months, subdivided into treatment groups UT+/severe, UT+/mild, UT–/severe, and UT–/mild. Difference between WAST scores of UT+ and UT– patients: p < 0.001; difference between severe and mild CH patients in the UT+ group: p < 0.001. OT, overtreatment; UT, undertreatment; Sev, severe.