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. 2019 Apr 24;10:878. doi: 10.3389/fimmu.2019.00878

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Copyright © 2019 del Pino-Molina, Rodríguez-Ubreva, Torres Canizales, Coronel-Díaz, Kulis, Martín-Subero, van der Burg, Ballestar and López-Granados.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DNA methylation levels for the selected CpG in different genes, in the naïve, unswitched (USm) and switched (Sm) memory B cells represented as percentage in box and whiskers. HD are represented in blue. CVID patients with normal numbers of unswitched (USm) and switched (Sm) memory B cells in red, CVID patients with normal numbers of unswitched (USm) memory B cells but reduced switched (Sm) memory B cells in orange; in green CVID patients with reduced numbers of both unswitched (USm) and switched (Sm) memory B cells. Box represent mean with minimum to maximum. The P-value is shown for the cases with a statistically significant difference by Mann Whitney test (*p < 0.05; **p < 0.01; ***p < 0.001).